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Issue 10, 2013
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Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

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Abstract

Poly(arginine) mimics bearing long hydrophobic side chains adopt a stable helical conformation and exhibit helix-related cell-penetrating properties. Elongating the polypeptide backbone length and increasing side chain hydrophobicity further increase the helicities of poly(arginine) mimics. These helical poly(arginine) mimics show superior cell membrane permeability up to two orders of magnitude higher than that of HIV-TAT peptide and excellent DNA and siRNA delivery efficiencies in various mammalian cells.

Graphical abstract: Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

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Supplementary files

Article information


Submitted
13 May 2013
Accepted
12 Jul 2013
First published
09 Aug 2013

Chem. Sci., 2013,4, 3839-3844
Article type
Edge Article

Helical poly(arginine) mimics with superior cell-penetrating and molecular transporting properties

H. Tang, L. Yin, K. H. Kim and J. Cheng, Chem. Sci., 2013, 4, 3839
DOI: 10.1039/C3SC51328A

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