Jump to main content
Jump to site search

Issue 6, 2013
Previous Article Next Article

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Author affiliations

Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are potential drug carriers and a magnetic resonance imaging (MRI) contrast agent for cancer therapy and diagnosis. In this study, dechlorinated cisplatin (CMDP) is tethered to maghemite nanoparticles modified with 4-oxo-4-(3-(triethoxysilyl)propylamino)butanoic acid (OTPBA–SPION) through the surface carboxylate groups. The nanocomposite (CMDP–OTPBA–SPION) was characterized by TEM, XPS, EDX, SQUID, ICP-AES, and zeta potential. A relatively high Pt loading capacity (ca. 13%) is achieved with this drug delivery system. The DNA binding ability of CMDP–OTPBA–SPION is prominent in acidic medium (pH 5.2) but is insignificant under normal physiological conditions (pH 7.4), suggesting that an acidic cancerous environment is favourable for the release of the platinum pharmacophore from the composite. The transverse relaxivity of CMDP–OTPBA–SPION in phosphate-buffered saline is 141.9 mM−1 s−1 in terms of Fe concentration, implying that the composite could be used as a negative-contrast agent for MRI. The cytotoxicity of the composite toward MCF-7 and HeLa cancer cells displays slow and time-dependent characteristics, reaching a level comparable to that of cisplatin at 72 h. The diagnostic capability and tumor-specific accumulation of the composite are verified in vitro and in vivo by the time-dependent negative-contrast enhancement effect in MRI using MCF-7 cells and tumor-bearing mice, respectively. The results demonstrate that CMDP–OTPBA–SPION can potentially be used as an anticancer theranostic agent for simultaneous targeted therapy and MRI under an external magnetic field.

Graphical abstract: A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Back to tab navigation

Supplementary files

Article information


Submitted
26 Feb 2013
Accepted
11 Apr 2013
First published
15 Apr 2013

Chem. Sci., 2013,4, 2605-2612
Article type
Edge Article

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

J. Wang, X. Wang, Y. Song, J. Wang, C. Zhang, C. Chang, J. Yan, L. Qiu, M. Wu and Z. Guo, Chem. Sci., 2013, 4, 2605
DOI: 10.1039/C3SC50554E

Social activity

Search articles by author

Spotlight

Advertisements