Issue 4, 2013
From the journal:

Chemical Science

Tuning colourimetric indicator displacement assays for naked-eye sensing of pyrophosphate in aqueous media†

Xuejian Liu,‡a   Huy Tien Ngo,‡a   Zijun Ge,a   Stephen J. Butlera  and  Katrina A. Jolliffe*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, NSW, Australia
E-mail: kate.jolliffe@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 2297

Abstract

A library of anion receptors comprising cyclic peptide scaffolds bearing two (ZnII-DPA) anion binding sites have been synthesised and their anion binding abilities evaluated using colourimetric indicator displacement assays with three different indicators. The resulting chemosensing ensembles provided excellent discrimination between polyphosphate ions, with several of the receptor : indicator combinations providing naked-eye sensing of pyrophosphate ions in aqueous solutions containing more than 100 fold excess of ATP.

Graphical abstract: Tuning colourimetric indicator displacement assays for naked-eye sensing of pyrophosphate in aqueous media

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Article information

DOI
https://doi.org/10.1039/C3SC22233K
Article type
Edge Article
Submitted
14 Dec 2012
Accepted
30 Jan 2013
First published
31 Jan 2013
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2013,4, 1680-1686

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Tuning colourimetric indicator displacement assays for naked-eye sensing of pyrophosphate in aqueous media

X. Liu, H. T. Ngo, Z. Ge, S. J. Butler and K. A. Jolliffe, Chem. Sci., 2013, 4, 1680 DOI: 10.1039/C3SC22233K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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