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Issue 10, 2012
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Reactive protein-repellent surfaces for the straightforward attachment of small molecules up to whole cells

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Abstract

Here we present a readily accessible strategy for creating protein-resistant surfaces that contain azides, based on the spontaneous adsorption of a comb-like copolymer. Using a strain-promoted azide alkyne cycloaddition, we illustrate the single-step conjugation of various representatives of important applications, being the labelling with small organic molecules, capture of nanoparticles, attachment of native enzymes at a controlled density, and finally control of cell adhesion. We thus demonstrate that advanced biomaterials can be created in two straightforward steps without requiring additional reagents, which should make this strategy a valuable tool for researchers in diverse fields.

Graphical abstract: Reactive protein-repellent surfaces for the straightforward attachment of small molecules up to whole cells

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Supplementary files

Article information


Submitted
23 May 2012
Accepted
04 Jul 2012
First published
05 Jul 2012

Chem. Sci., 2012,3, 3000-3006
Article type
Edge Article

Reactive protein-repellent surfaces for the straightforward attachment of small molecules up to whole cells

S. F. M. van Dongen, J. Janvore, S. S. van Berkel, E. Marie, M. Piel and C. Tribet, Chem. Sci., 2012, 3, 3000
DOI: 10.1039/C2SC20652H

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