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Issue 10, 2012
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A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

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Abstract

We discovered a novel small-molecule modulator 5{i,2} that can specifically induce the chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Based on our biochemical and histological studies, 5{i,2} showed more of a directed differentiation of MSCs to chondrocyte balls compared to TGF-β3.

Graphical abstract: A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

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Article information


Submitted
23 Mar 2012
Accepted
12 Jul 2012
First published
12 Jul 2012

Chem. Sci., 2012,3, 3071-3075
Article type
Edge Article

A potent small-molecule inducer of chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells

T. Cho, J. Kim, S. Kwon, K. Oh, J. Lee, D. Lee, J. Cho and S. B. Park, Chem. Sci., 2012, 3, 3071
DOI: 10.1039/C2SC20362F

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