Issue 6, 2012

Asymmetric catalytic epoxidation of α,β-unsaturated carbonyl compounds with hydrogen peroxide: Additive-free and wide substrate scope

Abstract

A simple and H2O2-efficient asymmetric epoxidation of α,β-unsaturated carbonyl compounds was accomplished using a chiral N,N′-dioxide–Sc(III) complex catalyst. A number of optically active epoxides were obtained from the corresponding α,β-unsaturated ketones and α,β-unsaturated amides under additive-free conditions. The catalytic system is convenient with good water- and air-tolerance, as well as excellent yields and enantioselectivities.

Graphical abstract: Asymmetric catalytic epoxidation of α,β-unsaturated carbonyl compounds with hydrogen peroxide: Additive-free and wide substrate scope

Supplementary files

Article information

Article type
Edge Article
Submitted
22 Feb 2012
Accepted
09 Mar 2012
First published
12 Mar 2012

Chem. Sci., 2012,3, 1996-2000

Asymmetric catalytic epoxidation of α,β-unsaturated carbonyl compounds with hydrogen peroxide: Additive-free and wide substrate scope

Y. Chu, X. Liu, W. Li, X. Hu, L. Lin and X. Feng, Chem. Sci., 2012, 3, 1996 DOI: 10.1039/C2SC20218B

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