Jump to main content
Jump to site search

Issue 6, 2012
Previous Article Next Article

Enantioselective rhodium-catalyzed allylic alkylation of acyclic α-alkoxy substituted ketones using a chiral monodentate phosphite ligand

Author affiliations

Abstract

A highly enantioselective rhodium-catalyzed allylic alkylation of acyclic α-alkoxy aryl ketones utilizing the complex derived from Wilkinson's catalyst and the chiral monodentate phosphite, BINOL-MeOP, has been developed. This process represents the first enantioselective rhodium-catalyzed allylic substitution with a prochiral nucleophile. The ability to transform the aryl ketones into the corresponding alcohol and ester illustrates the potential utility of this transformation for target directed synthesis.

Graphical abstract: Enantioselective rhodium-catalyzed allylic alkylation of acyclic α-alkoxy substituted ketones using a chiral monodentate phosphite ligand

Back to tab navigation

Supplementary files

Article information


Submitted
02 Feb 2012
Accepted
21 Feb 2012
First published
27 Mar 2012

Chem. Sci., 2012,3, 1835-1838
Article type
Edge Article

Enantioselective rhodium-catalyzed allylic alkylation of acyclic α-alkoxy substituted ketones using a chiral monodentate phosphite ligand

P. A. Evans, E. A. Clizbe, M. J. Lawler and S. Oliver, Chem. Sci., 2012, 3, 1835
DOI: 10.1039/C2SC20141K

Social activity

Search articles by author

Spotlight

Advertisements