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Issue 6, 2012
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Exploration of plasticizer and plastic explosive detection and differentiation with serum albumin cross-reactive arrays

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Abstract

Plastic explosives, such as Semtex and C4, are commonly used explosive mixtures. The differentiation and detection of the plasticizers within these mixtures could provide information for anti-terrorism and combat activities. In this study, we demonstrate a strategy of using cross-reactive serum albumin proteins to differentiate and detect the plasticizers found within these explosive mixtures. With our sensing ensemble, comprised of serum albumins, fluorescent indicators and an additive, we successfully classified the five plasticizers found within Semtex and C4 using linear discriminate analysis, and differentiated simulated Semtex and C4 mixtures based on surrogates of the explosive material(s) and the plasticizer composition in these samples. Finally, we have shown the utility of this type of cross-reactive array for real life use in a battlefield setting by examining these mixtures in the presence of soil contamination.

Graphical abstract: Exploration of plasticizer and plastic explosive detection and differentiation with serum albumin cross-reactive arrays

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Supplementary files

Article information


Submitted
17 Jan 2012
Accepted
05 Mar 2012
First published
07 Mar 2012

Chem. Sci., 2012,3, 1773-1779
Article type
Edge Article

Exploration of plasticizer and plastic explosive detection and differentiation with serum albumin cross-reactive arrays

M. A. Ivy, L. T. Gallagher, A. D. Ellington and E. V. Anslyn, Chem. Sci., 2012, 3, 1773
DOI: 10.1039/C2SC20083J

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