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Issue 7, 2012
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Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

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Abstract

Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these molecules. One of them, the azide-aza-bisbenzamidine 13, can be readily modified via click-chemistry with a variety of functionalities that can, therefore, be delivered to the vicinity of an A/T-rich DNA minor groove. This strategy, therefore, provides a simple means for triggering site selective, DNA-promoted biochemical and physicochemical processes.

Graphical abstract: Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

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Article information


Submitted
08 Jan 2012
Accepted
01 May 2012
First published
01 May 2012

Chem. Sci., 2012,3, 2383-2387
Article type
Edge Article

Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes

M. I. Sánchez, O. Vázquez, J. Martínez-Costas, M. E. Vázquez and J. L. Mascareñas, Chem. Sci., 2012, 3, 2383
DOI: 10.1039/C2SC00027J

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