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Issue 2, 2012
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Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives

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Abstract

We report the synthesis and study of a new guanosine-based hydrogelator, 8-methoxy-2′,3′,5′-tri-O-acetylguanosine, that can not only gel aqueous solutions at biologically relevant salt concentrations, but can also gel cell media. Studies suggest that this hydrogelator forms helical assemblies, rather than the macrocyclic quartet assemblies commonly found in guanosine hydrogels, which allow it to form hydrogels at as low as 0.5 wt% in 100mM NaCl. Furthermore, we show that this gelator is non-toxic to cells, injectable and that by simply mixing with 2′,3′,5′-tri-O-acetylguanosine, we can systematically vary the modulus and shear sensitivity of the gel over orders of magnitude.

Graphical abstract: Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives

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Publication details

The article was received on 27 Sep 2011, accepted on 08 Nov 2011 and first published on 24 Nov 2011


Article type: Edge Article
DOI: 10.1039/C1SC00729G
Citation: Chem. Sci., 2012,3, 564-572

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    Toward potential supramolecular tissue engineering scaffolds based on guanosine derivatives

    L. E. Buerkle, H. A. von Recum and S. J. Rowan, Chem. Sci., 2012, 3, 564
    DOI: 10.1039/C1SC00729G

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