Issue 9, 2011
From the journal:

Chemical Science

An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling†

Sharon Lai-Fung Chan,‡a   Raymond Wai-Yin Sun,‡a   Mei-Yuk Choi,a   Yibo Zeng,a   Lam Shek,a   Stephen Sin-Yin Chuia  and  Chi-Ming Che*a  

* Corresponding authors

a Department of Chemistry, State Key Laboratory of Synthetic Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852-2857 1586

Abstract

A new trinuclear ruthenium complex [RuIII3(TSA-H)2(TSA)4][NEt4] (1) with the non-toxic 2-thiosalicylic acid (TSA-H2) ligand could be prepared in a pure form and in a large quantity by a one-pot reaction. Complex 1 is stable under physiological conditions and forms adduct(s) with glutathione (GSH). It is anti-cancer active towards a panel of cancer cell lines, but does not exert its cytotoxicity through DNA binding. This is the first ruthenium complex reported to significantly attenuate the Wnt-β-catenin signaling in both transcriptomic and proteomic levels as demonstrated by DNA microarray, RT-PCR and Western blotting analyses.

Graphical abstract: An anti-cancer trinuclear ruthenium(iii) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling

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Article information

DOI
https://doi.org/10.1039/C1SC00203A
Article type
Edge Article
Submitted
31 Mar 2011
Accepted
27 May 2011
First published
07 Jul 2011

Chem. Sci., 2011,2, 1788-1792

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An anti-cancer trinuclear ruthenium(III) complex with 2-thiosalicylate ligands attenuates Wnt-β-catenin signaling

S. Lai-Fung Chan, R. Wai-Yin Sun, M. Choi, Y. Zeng, L. Shek, S. Sin-Yin Chui and C. Che, Chem. Sci., 2011, 2, 1788 DOI: 10.1039/C1SC00203A

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