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Issue 9, 2011
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Enamine/carbene cascade catalysis in the diastereo- and enantioselective synthesis of functionalized cyclopentanones

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Abstract

Herein we report an enantioselective synthesis of complex cyclopentanones using aliphatic aldehydes and activated enones. With the combination of a chiral secondary amine and a chiral triazolium catalyst, high diastereoselectivity and excellent enantioselectivity can be achieved. We present evidence of a clear cooperative effect when these two catalysts are present simultaneously in the system.

Graphical abstract: Enamine/carbene cascade catalysis in the diastereo- and enantioselective synthesis of functionalized cyclopentanones

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Publication details

The article was received on 22 Mar 2011, accepted on 23 May 2011 and first published on 16 Jun 2011


Article type: Edge Article
DOI: 10.1039/C1SC00175B
Chem. Sci., 2011,2, 1835-1838

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    Enamine/carbene cascade catalysis in the diastereo- and enantioselective synthesis of functionalized cyclopentanones

    K. E. Ozboya and T. Rovis, Chem. Sci., 2011, 2, 1835
    DOI: 10.1039/C1SC00175B

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