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Issue 7, 2011
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Highly enantioselective asymmetric Darzens reactions with a phase transfer catalyst

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Abstract

A class of easily accessible and readily tunable chiral phase transfer catalysts based on 6′-OH cinchonium salts was found to efficiently catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones and aldehydes, which directly produces optically active chiral epoxides from readily available carbonyl compounds.

Graphical abstract: Highly enantioselective asymmetric Darzens reactions with a phase transfer catalyst

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Article information


Submitted
07 Mar 2011
Accepted
31 Mar 2011
First published
21 Apr 2011

Chem. Sci., 2011,2, 1301-1304
Article type
Edge Article

Highly enantioselective asymmetric Darzens reactions with a phase transfer catalyst

Y. Liu, B. A. Provencher, K. J. Bartelson and L. Deng, Chem. Sci., 2011, 2, 1301
DOI: 10.1039/C1SC00137J

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