Issue 1, 2010

Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates

Abstract

Using a flexible synthesis, new chiral iridium N,P complexes with sterically demanding aryl substituents were synthesized and used in the asymmetric hydrogenation of difficult substrates. Unprecedented enantioselectivities were obtained in the asymmetric hydrogenation of α-substituted α,β-unsaturated esters and dihydronaphthalenes. The variety of aryl substituents incorporated into the catalyst has made it possible to obtain useful structure selectivity relationships for important classes of substrates.

Graphical abstract: Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates

Supplementary files

Article information

Article type
Edge Article
Submitted
10 Mar 2010
Accepted
15 Apr 2010
First published
12 May 2010

Chem. Sci., 2010,1, 72-78

Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates

D. H. Woodmansee, M. Müller, M. Neuburger and A. Pfaltz, Chem. Sci., 2010, 1, 72 DOI: 10.1039/C0SC00223B

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