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Issue 9, 2019
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Development of an automated kinetic profiling system with online HPLC for reaction optimization

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Abstract

Automated kinetic profiling is a valuable tool for providing insights into key mechanistic features of complex catalytic systems. In an attempt to optimize a palladium-catalyzed Suzuki cross-coupling reaction, automated kinetic profiling was utilized with offline liquid chromatography to monitor reaction progress. Upon uncovering analytical sample instability issues, an online HPLC capability was developed and implemented through integration of a Chemspeed liquid handling robot with an Agilent HPLC to facilitate automated reaction set-up and monitoring. Application of this capability resulted in the observation that precatalyst activation was a key factor influencing the reaction rate. Leveraging this mechanistic insight, a more efficient method to access the active catalyst was developed. This change resulted in a five-fold increase in the reaction rate.

Graphical abstract: Development of an automated kinetic profiling system with online HPLC for reaction optimization

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Supplementary files

Article information


Submitted
23 Feb 2019
Accepted
25 Mar 2019
First published
29 Mar 2019

React. Chem. Eng., 2019,4, 1555-1558
Article type
Communication

Development of an automated kinetic profiling system with online HPLC for reaction optimization

M. Christensen, F. Adedeji, S. Grosser, K. Zawatzky, Y. Ji, J. Liu, J. A. Jurica, J. R. Naber and J. E. Hein, React. Chem. Eng., 2019, 4, 1555
DOI: 10.1039/C9RE00086K

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