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Issue 5, 2018
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Sequential double C–H functionalization of 2,5-norbornadiene in flow

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Abstract

An anionic species of 2,5-norbornadiene was generated and brominated using a flow reactor. In the second step, 2-bromo-2,5-norbornadiene was lithiated with LTMP and reacted with tributyltin chloride. Finally, an integrated one-flow synthesis using various electrophiles was achieved within 3 min to prepare 2-bromo-2,5-norbornadienes bearing a functional group at the 3-position.

Graphical abstract: Sequential double C–H functionalization of 2,5-norbornadiene in flow

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Article information


Submitted
18 Jul 2018
Accepted
26 Jul 2018
First published
27 Jul 2018

React. Chem. Eng., 2018,3, 635-639
Article type
Communication

Sequential double C–H functionalization of 2,5-norbornadiene in flow

H. Kim, Z. Yin, H. Sakurai and J. Yoshida, React. Chem. Eng., 2018, 3, 635
DOI: 10.1039/C8RE00131F

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