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Issue 2, 2018
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Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

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Abstract

A hemiaminal derivative identified during preparation of the penultimate of ceftolozane 1, mandated a thorough investigation of the source of the impurity. N,N-Dimethylacetamide (DMAc) subjected to oxidation was found to be the culprit generating oxidized products that serve as sources of the hemiaminal derivative. Identification of DMAc as a source of formaldehyde derivatives and the mechanism of DMAc oxidation are elaborated.

Graphical abstract: Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

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Article information


Submitted
01 Dec 2017
Accepted
06 Feb 2018
First published
06 Feb 2018

React. Chem. Eng., 2018,3, 146-150
Article type
Communication

Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives

D. Zewge, X. Bu, H. Sheng, Y. Liu, Z. Liu, B. Harman, M. Reibarkh and X. Gong, React. Chem. Eng., 2018, 3, 146
DOI: 10.1039/C7RE00199A

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