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Issue 1, 2016
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Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

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Abstract

An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce >93% yield.

Graphical abstract: Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

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Supplementary files

Article information


Submitted
20 Oct 2015
Accepted
25 Nov 2015
First published
01 Dec 2015

React. Chem. Eng., 2016,1, 96-100
Article type
Paper
Author version available

Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

N. Holmes, G. R. Akien, R. J. D. Savage, C. Stanetty, I. R. Baxendale, A. J. Blacker, B. A. Taylor, R. L. Woodward, R. E. Meadows and R. A. Bourne, React. Chem. Eng., 2016, 1, 96
DOI: 10.1039/C5RE00083A

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