Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

Nicolai A. Aksenov; Dmitrii A. Aksenov; Igor A. Kurenkov; Alexander V. Aksenov; Anton A. Skomorokhov; Lidiya A. Prityko; Michael Rubin

doi:10.1039/D1RA02279B

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Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones†

Nicolai A. Aksenov,

*^a Dmitrii A. Aksenov,

^a Igor A. Kurenkov,

^a Alexander V. Aksenov,

^a Anton A. Skomorokhov,^a Lidiya A. Prityko

^a and Michael Rubin

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355009, Russian Federation
E-mail: aaksenov@ncfu.ru

^b Department of Chemistry, University of Kansas, 1567 Irving Hill Rd, Lawrence, KS 66045-7582, USA
E-mail: mrubin@ku.edu
Tel: +1-785-864-5071

Abstract

A convenient preparative method is developed allowing for expeditious assembly of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones from routinely available inexpensive synthetic precursors. These compounds could not be prepared via the previously known protocols, as 2-aminofuran derivatives were produced instead.

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DOI: https://doi.org/10.1039/D1RA02279B
Article type: Paper
Submitted: 22 Mar 2021
Accepted: 13 Apr 2021
First published: 30 Apr 2021
This article is Open Access

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RSC Adv., 2021,11, 16236-16245

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Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

N. A. Aksenov, D. A. Aksenov, I. A. Kurenkov, A. V. Aksenov, A. A. Skomorokhov, L. A. Prityko and M. Rubin, RSC Adv., 2021, 11, 16236 DOI: 10.1039/D1RA02279B

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Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones†

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Preparation of 3,5-diarylsubstituted 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones via base-assisted cyclization of 3-cyanoketones

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