Issue 25, 2021, Issue in Progress

Catalyst-free one-pot, four-component approach for the synthesis of di- and tri-substituted N-sulfonyl formamidines

Abstract

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN3, ethyl propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural analysis of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogues only formed E-isomers.

Graphical abstract: Catalyst-free one-pot, four-component approach for the synthesis of di- and tri-substituted N-sulfonyl formamidines

Supplementary files

Article information

Article type
Paper
Submitted
29 Jan 2021
Accepted
12 Apr 2021
First published
27 Apr 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 15161-15166

Catalyst-free one-pot, four-component approach for the synthesis of di- and tri-substituted N-sulfonyl formamidines

A. Liu, L. Zhang, J. Li and A. Wusiman, RSC Adv., 2021, 11, 15161 DOI: 10.1039/D1RA00772F

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