Issue 59, 2020
From the journal:

RSC Advances

A biotin-guided hydrogen sulfide fluorescent probe and its application in living cell imaging†

Chen Zhang,‡a   Jiewen Zhang,‡a   Zhiqiang Xu,b   Kun Zang,a   Feng Liu,a   Jun Yin, ORCID logo *b   Ying Tan ORCID logo *a  and  Yuyang Jiangc  

* Corresponding authors

a State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, P. R. China
E-mail: tan.ying@il.ccnu.edu.cn

b Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
E-mail: yinj@mail.ccnu.edu.cn

c School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, P. R. China

Abstract

Hydrogen sulfide (H2S), a well-known signaling molecule, exerts significant regulatory effects on the cardiovascular and nervous systems. Therefore, monitoring the metabolism of H2S offers a potential mechanism to detect various diseases. In addition, biotin is significantly used as a targeting group to detect cancer cells exclusively. In this work, a biotin-guided benzoxadizole-based fluorescent probe, NP-biotin, was developed for H2S detection and evaluated in normal liver cell (LO2) and liver cancer cell (HepG2) lines. Results reveal that NP-biotin can detect cellular H2S with high sensitivity and selectivity. Moreover, NP-biotin has been confirmed to possess the ability to target cancer cells under the guidance of the biotin group.

Graphical abstract: A biotin-guided hydrogen sulfide fluorescent probe and its application in living cell imaging

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Article information

DOI
https://doi.org/10.1039/D0RA06524B
Article type
Paper
Submitted
28 Jul 2020
Accepted
14 Sep 2020
First published
01 Oct 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 36135-36140

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A biotin-guided hydrogen sulfide fluorescent probe and its application in living cell imaging

C. Zhang, J. Zhang, Z. Xu, K. Zang, F. Liu, J. Yin, Y. Tan and Y. Jiang, RSC Adv., 2020, 10, 36135 DOI: 10.1039/D0RA06524B

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