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Issue 26, 2020, Issue in Progress
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PVP-coated Sb2Se3 nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows

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Abstract

Antimony selenide (Sb2Se3) as a simple, low toxicity, low-cost p-type semiconductor material with broad absorbance ranging from the UV to the NIR region has many potential applications in photovoltaic, thermoelectric, and phase-change memory devices. Owing to these excellent properties, Sb2Se3 nanorods were firstly synthesized with triphenylantimony and dibenzyldiselenide under solvothermal conditions. In order to enhance the biocompatibility of the Sb2Se3 nanorods, polyvinylpyrrolidone (PVP) was coated onto the surface of the Sb2Se3 nanorods to form PVP-coated Sb2Se3 nanorods. The cell viability of PVP-coated Sb2Se3 nanorods toward Hep-2 cells was assessed for 24 h using a Cell Counting Kit-8 (CCK-8) assay. The results showed that Hep-2 cells treated with PVP-coated Sb2Se3 nanorods were alive at a concentration as high as 100 μg mL−1 in the absence of NIR irradiation. In vivo assessment confirmed that PVP-coated Sb2Se3 nanorods exhibited excellent photoacoustic imaging and PTT performance, which yielded complete ablation of tumors after laser irradiation (808 nm or 980 nm) in the NIR-I bio-window.

Graphical abstract: PVP-coated Sb2Se3 nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows

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Supplementary files

Article information


Submitted
20 Feb 2020
Accepted
07 Apr 2020
First published
17 Apr 2020

This article is Open Access

RSC Adv., 2020,10, 15221-15227
Article type
Paper

PVP-coated Sb2Se3 nanorods as nanotheranostic agents for photoacoustic imaging and photothermal therapy in NIR-I bio-windows

B. Qu, X. Li, X. Zhang, W. Li and R. Zhang, RSC Adv., 2020, 10, 15221
DOI: 10.1039/D0RA01638A

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    [Original citation] - Published by The Royal Society of Chemistry.

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