Issue 21, 2020
From the journal:

RSC Advances

Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography†

Giulia Mazzoccanti, ORCID logo *a   Simone Manetto,a   Michele Bassan,b   Alberto Foschini,b   Andrea Orlandin,b   Antonio Ricci,*b   Walter Cabri,bc   Omar H. Ismail,d   Martina Catani,d   Alberto Cavazzini ORCID logo d  and  Francesco Gasparrini ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Chemistry and Technology, “Sapienza” University of Rome, Rome, Italy
E-mail: francesco.gasparrini@uniroma1.it, giulia.mazzoccanti@uniroma1.it

b Fresenius Kabi iPSUM, Piazza Maestri del Lavoro 7, Cernusco sul Naviglio, MI, Italy
E-mail: antonio.ricci@fresenius-kabi.com

c Department of Chemistry, Alma Mater Studiorum-University of Bologna, Via Selmi2, 40126 Bologna, Italy

d Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy

Abstract

The application of a novel chromatographic approach to therapeutic peptides bearing basic amino acids in their structure allowed unprecedented resolution of their related impurities (including epimeric isobaric ones), resulting in a superior analytical tool for the evaluation of the quality of these drugs in the market.

Graphical abstract: Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

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Article information

DOI
https://doi.org/10.1039/D0RA01296C
Article type
Paper
Submitted
10 Feb 2020
Accepted
23 Mar 2020
First published
27 Mar 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 12604-12610

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Boosting basic-peptide separation through dynamic electrostatic-repulsion reversed-phase (d-ERRP) liquid chromatography

G. Mazzoccanti, S. Manetto, M. Bassan, A. Foschini, A. Orlandin, A. Ricci, W. Cabri, O. H. Ismail, M. Catani, A. Cavazzini and F. Gasparrini, RSC Adv., 2020, 10, 12604 DOI: 10.1039/D0RA01296C

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