Jump to main content
Jump to site search

Issue 25, 2020
Previous Article Next Article

Reaction-diffusion model as framework for understanding the role of riboflavin in “eye defence” formulations

Author affiliations

Abstract

Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, Ct, such that for riboflavin concentration > Ct the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion–reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.

Graphical abstract: Reaction-diffusion model as framework for understanding the role of riboflavin in “eye defence” formulations

Back to tab navigation

Article information


Submitted
14 Jan 2020
Accepted
04 Apr 2020
First published
16 Apr 2020

This article is Open Access

RSC Adv., 2020,10, 14965-14971
Article type
Paper

Reaction-diffusion model as framework for understanding the role of riboflavin in “eye defence” formulations

F. Di Nezza, C. Caruso, C. Costagliola and L. Ambrosone, RSC Adv., 2020, 10, 14965
DOI: 10.1039/D0RA00417K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements