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Issue 9, 2020, Issue in Progress
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Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents

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Abstract

Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.

Graphical abstract: Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents

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Article information


Submitted
27 Nov 2019
Accepted
17 Jan 2020
First published
31 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 5191-5195
Article type
Paper

Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a]pyrimidines as potential anti-chikungunya agents

M. Fares, P. M. McCosker, M. A. Alsherbiny, A. C. Willis, T. Clark, J. Neyts, D. Jochmans and P. A. Keller, RSC Adv., 2020, 10, 5191
DOI: 10.1039/D0RA00257G

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