Issue 7, 2020, Issue in Progress

Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

Abstract

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.

Graphical abstract: Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

Supplementary files

Article information

Article type
Paper
Submitted
09 Jan 2020
Accepted
16 Jan 2020
First published
23 Jan 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 3946-3950

Efficient synthesis of 1-iodoalkynes via Al2O3 mediated reaction of terminal alkynes and N-iodosuccinimide

M. Yao, J. Zhang, S. Yang, H. Xiong, L. Li, E. Liu and H. Shi, RSC Adv., 2020, 10, 3946 DOI: 10.1039/D0RA00251H

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