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Issue 8, 2020, Issue in Progress
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Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

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Abstract

Harmane, a compound derived from Peganum harmala L., was discovered as a lipid accumulation inhibitor with our triglyceride (TG) assay. To investigate the molecular mechanism underlying the role of harmane in the prevention of lipid accumulation, a number of biological experiments have been designed to determine if harmane reduces lipid accumulation by suppressing adipogenesis, lipogenesis, and regulating a specific signal transduction pathway. Our experimental data show that harmane inhibits TG accumulation though down-regulating the expression of adipogenic and lipogenic factors, up-regulating adipocyte browning markers and activating the SIRT1-LKB1-AMPK pathway. Therefore, harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning.

Graphical abstract: Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

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Article information


Submitted
11 Nov 2019
Accepted
10 Jan 2020
First published
27 Jan 2020

This article is Open Access

RSC Adv., 2020,10, 4397-4403
Article type
Paper

Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Y. Li, C. Li, J. Wu, W. Liu, D. Li and J. Xu, RSC Adv., 2020, 10, 4397
DOI: 10.1039/C9RA09383D

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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