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Issue 69, 2019
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Nanoparticle modification in biological media: implications for oral nanomedicines

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Abstract

Nanomedicine has shown potential in enabling oral administration of poorly absorbable drugs, such as biologics. As part of the process related to optimisation of the safety and efficacy of nanomedicines, it is imperative that the interaction of nanoparticles with the biological systems – including the gut – is fully characterised. In this article, we provide an overview of the major mechanisms by which nanoparticles may transform upon introduction in biological media. Specifically, the phenomena of association, dissolution and biomolecule adsorption are discussed, together with factors which influence the occurrence of each phenomenon. The implications of these phenomena within the context of therapeutic action of nanomedicines, which includes reduced targeting efficiency, are also explored. Finally, we will comment on nanoparticle modification within the gut environment, including the currently available gastrointestinal models for the study of nano-bio interactions, with implications in the area of nanomedicines for oral administration.

Graphical abstract: Nanoparticle modification in biological media: implications for oral nanomedicines

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Article information


Submitted
14 Oct 2019
Accepted
28 Nov 2019
First published
06 Dec 2019

This article is Open Access

RSC Adv., 2019,9, 40487-40497
Article type
Review Article

Nanoparticle modification in biological media: implications for oral nanomedicines

V. Muraleetharan, J. Mantaj, M. Swedrowska and D. Vllasaliu, RSC Adv., 2019, 9, 40487 DOI: 10.1039/C9RA08403G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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