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Issue 42, 2019, Issue in Progress
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Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

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Abstract

An efficient protocol for the synthesis of 2,2-disubstituted indolin-3-ones under mild conditions has been developed. This reaction involves the copper-catalyzed in situ oxidative de-aromatization of 2-arylindoles to indol-3-one, followed by self-dimerization as well as cross-addition with indoles under mild conditions. The result generates a wide variety of C2-tetrasubstituted indolin-3-ones with good to high yields (62–82%).

Graphical abstract: Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

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Supplementary files

Article information


Submitted
24 Jun 2019
Accepted
23 Jul 2019
First published
02 Aug 2019

This article is Open Access

RSC Adv., 2019,9, 24050-24056
Article type
Paper

Synthesis of C2-tetrasubstituted indolin-3-ones via Cu-catalyzed oxidative dimerization of 2-aryl indoles and cross-addition with indoles

A. Singh, S. Vanaparthi, S. Choudhary, R. Krishnan and I. Kumar, RSC Adv., 2019, 9, 24050
DOI: 10.1039/C9RA04741G

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