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Issue 40, 2019, Issue in Progress
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A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor

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Abstract

In this study, we aimed to develop a cellulose/β-cyclodextrin (β-CD) electrospun immobilized GOx enzyme patch with reverse iontophoresis for noninvasive monitoring of interstitial fluid (ISF) glucose levels (0.1–0.6 mM dm−3). In vitro analysis, performed using a sensor attached to flexible substrates, revealed that the high diffusion coefficient (9.0 × 10−5 cm2 s−1), the linear correlation coefficient (R2 = 0.998), the detection limit (9.35 × 10−5 M), and the linear range sensitivity (0–1 mM) of the sensor (5.08 μA mM−1) remained unaffected by the presence of interfering substances (e.g., fructose, sucrose, uric acid, and acetaminophen) at physiological levels. The present results indicate that the new epidermal sensing strategy using nanofibers for continuous glucose monitoring has potential to be applied in diagnosis of diabetes.

Graphical abstract: A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor

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Publication details

The article was received on 27 May 2019, accepted on 01 Jul 2019 and first published on 23 Jul 2019


Article type: Paper
DOI: 10.1039/C9RA03887F
RSC Adv., 2019,9, 22790-22794
  • Open access: Creative Commons BY license
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    A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor

    K. O. Kim, G. J. Kim and J. H. Kim, RSC Adv., 2019, 9, 22790
    DOI: 10.1039/C9RA03887F

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