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Issue 34, 2019, Issue in Progress
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Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

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Abstract

Micronutrients administration by fortification of staple and complementary foods is a followed strategy to fight malnutrition and micronutrient deficiencies and related pathologies. There is a great industrial interest in preparation of formulations for joint administration of vitamin D3 and vitamin K2 for providing bone support, promoting heart health and helping boost immunity. To respond to this topic, in this work, uncoated nanoliposomes loaded with vitamin D3 and K2 were successfully prepared, by using a novel, high-yield and semi continuous technique based on simil-microfluidic principles. By the same technique, to promote and to enhance mucoadhesiveness and stability of the produced liposomal structures, chitosan was tested as covering material. By this way polymer–lipid hybrid nanoparticles, encapsulating vitamin D3 and vitamin K2, with improved features in terms of stability, loading and mucoadhesiveness were produced for potential nutraceutical and pharmaceutical applications.

Graphical abstract: Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

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Article information


Submitted
23 Apr 2019
Accepted
14 Jun 2019
First published
25 Jun 2019

This article is Open Access

RSC Adv., 2019,9, 19800-19812
Article type
Paper

Micronutrients encapsulation in enhanced nanoliposomal carriers by a novel preparative technology

A. Dalmoro, S. Bochicchio, G. Lamberti, P. Bertoncin, B. Janssens and A. A. Barba, RSC Adv., 2019, 9, 19800
DOI: 10.1039/C9RA03022K

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    [Original citation] - Published by The Royal Society of Chemistry.

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