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Issue 37, 2019
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Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit

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Abstract

The chemical composition and biological properties of palm Washingtonia filifera (Lindl.) H. Wendl. seeds are seldom studied. Bearing this in mind, the seeds of W. filifera fruits were analysed for their fatty acid and phenolic composition and their antioxidant activity in addition to their cholinesterase and xanthine oxidase inhibitory activities. Seed extracts were revealed as a good source of phenolics with significant antioxidant activity. The phenolic profile mainly consisted of proanthocyanidins or procyanidin dimers B1–B4 among the major compounds. The highest butyrylcholinesterase inhibitory activity was found in the ethanolic extracts of seeds, with IC50 values of 13.73 ± 1.31 μg mL−1. Seed alcoholic extracts also displayed interesting xanthine oxidase inhibitory activity, with IC50 values ranging between 75.2 ± 17.0 μg mL−1 and 95.8 ± 5.9 μg mL−1. Procyanidin B1, a major component in the extracts, could be an important contributor to that activity, as it was found to possess good xanthine oxidase inhibition capacity (IC50 value of 53.51 ± 6.03 μg mL−1). Docking studies were also performed to predict the binding sites of procyanidins B1 and B2 within the xanthine oxidase structure. In all, W. filifera seeds appear as a promising natural source for the extraction of bioactive compounds with antioxidant and butyrylcholinesterase as well as xanthine oxidase inhibitory potential.

Graphical abstract: Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit

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Supplementary files

Article information


Submitted
18 Apr 2019
Accepted
25 Jun 2019
First published
08 Jul 2019

This article is Open Access

RSC Adv., 2019,9, 21278-21287
Article type
Paper

Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit

S. Floris, A. Fais, A. Rosa, A. Piras, H. Marzouki, R. Medda, A. M. González-Paramás, A. Kumar, C. Santos-Buelga and B. Era, RSC Adv., 2019, 9, 21278
DOI: 10.1039/C9RA02928A

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    [Original citation] - Published by The Royal Society of Chemistry.

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