Issue 27, 2019, Issue in Progress

Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

Abstract

A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pre-treatment and colocalizes with lipid droplets.

Graphical abstract: Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

Supplementary files

Article information

Article type
Paper
Submitted
09 Mar 2019
Accepted
19 Apr 2019
First published
16 May 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 15350-15356

Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose

A. Locatelli, L. Iommarini, A. Graziadio, A. Leoni, A. M. Porcelli, S. Iotti, E. Malucelli, F. Francia, G. Venturoli and G. Farruggia, RSC Adv., 2019, 9, 15350 DOI: 10.1039/C9RA01800J

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