Issue 37, 2019

Solidly mounted resonator sensor for biomolecule detections

Abstract

We report the fabrication of a solidly mounted resonator (SMR) that can also function as a sensor for biological molecules. The SMR, consisting of a Au electrode, aluminum nitride (AlN) piezoelectric thin film and Bragg acoustic reflector, was fabricated on a Si substrate by radio frequency (RF) magnetron sputtering. The Bragg acoustic reflector, made entirely of metal, has small internal stress and good heat conduction. Human immunoglobulin G (IgG) antibody was immobilized on the modified (by self-assembled monolayer method) Au electrode surface of the SMR and goat anti-human IgG antigen was captured through the specificity of bond between the antibody and antigen on the electrode surface. We found a linear relationship between the resonant frequency shift and the concentration of goat anti-human IgG antigen for concentrations smaller than 0.4 mg ml−1 and a relatively constant frequency shift for concentrations greater than 0.5 mg ml−1. A series of interference experiments can prove that the selectivity of the sensor is satisfactory. Our findings suggest that the SMR sensor is an attractive alternative for biomolecule detection.

Graphical abstract: Solidly mounted resonator sensor for biomolecule detections

Article information

Article type
Paper
Submitted
06 Mar 2019
Accepted
30 Jun 2019
First published
09 Jul 2019
This article is Open Access
Creative Commons BY license

RSC Adv., 2019,9, 21323-21328

Solidly mounted resonator sensor for biomolecule detections

C. Han, X. Wang, Q. Zhao, L. Teng, S. Zhang, H. Lv, J. Liu, H. Ma and Y. Wang, RSC Adv., 2019, 9, 21323 DOI: 10.1039/C9RA01695C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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