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Issue 4, 2019
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Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice

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Abstract

The aim of this study was to isolate maltol derivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltol in a 2,4-dinitrochlorobenzene (DNCB)-sensitized mouse model of AD. A novel compound, maltol 3-O-(4′-O-cis-p-coumaroyl)-β-D-glucoside (named isosoyamaloside I), and two known maltol derivatives (maltol and soyamaloside I) were isolated from S. chamaejasme using chromatographic methods. Dermal application of maltol to DNCB-sensitized AD mice reduced erythema, pruritus, and lichenification scores. Histopathological examinations revealed significant decline in mast cell infiltration in maltol-treated AD mice. In addition, maltol accelerated skin barrier recovery by reducing TEWL and skin pH and increasing skin hydration. Maltol was also found to suppress atopy-induced IL-4 and IgE elevations in serum, which are known to be essential for the development of atopy. The results of this study show that maltol is a potential therapeutic candidate for the treatment of AD-related skin diseases.

Graphical abstract: Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice

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Publication details

The article was received on 27 Nov 2018, accepted on 18 Dec 2018 and first published on 15 Jan 2019


Article type: Paper
DOI: 10.1039/C8RA09743G
RSC Adv., 2019,9, 2125-2132
  • Open access: Creative Commons BY license
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    Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice

    B. Jo, N. Park, S. Kim, J. Jegal, S. Choi, S. W. Lee, L. W. Yi, S. R. Lee, K. H. Kim and M. H. Yang, RSC Adv., 2019, 9, 2125
    DOI: 10.1039/C8RA09743G

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