Jump to main content
Jump to site search

Issue 73, 2018
Previous Article Next Article

Microwave irradiation: a green approach for the synthesis of functionalized N-methyl-1,4-dihydropyridines

Author affiliations

Abstract

An eco-friendly and cost-effective, microwave-assisted green approach has been developed for the synthesis of diverse functionalized N-methyl-1,4-dihydropyridines (1,4-DHPs). This pseudo three-component reaction was carried out between two equivalents of (E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) and one equivalent of aromatic aldehydes under microwave irradiation at 100 °C without catalyst and solvent. Short reaction times, avoidance of toxic solvents or expensive, metallic and corrosive catalysts and no need for column chromatographic purification are among the valuable features of the presented method. Moreover, the “greenness” of the method was evaluated within the ambits of the defined green metrics such as atom economy, carbon efficiency, E-factor, reaction mass efficiency, overall efficiency, process mass intensity and solvent intensity and the method exhibited a good to excellent score.

Graphical abstract: Microwave irradiation: a green approach for the synthesis of functionalized N-methyl-1,4-dihydropyridines

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Nov 2018, accepted on 28 Nov 2018 and first published on 14 Dec 2018


Article type: Paper
DOI: 10.1039/C8RA09155B
RSC Adv., 2018,8, 41892-41903
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Microwave irradiation: a green approach for the synthesis of functionalized N-methyl-1,4-dihydropyridines

    M. M. Khan, Saigal, S. Khan, S. Shareef and S. C. Sahoo, RSC Adv., 2018, 8, 41892
    DOI: 10.1039/C8RA09155B

    This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements