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Issue 74, 2018

A GSH-responsive nanophotosensitizer for efficient photodynamic therapy

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Abstract

Photodynamic therapy (PDT) is a promising cancer treatment modality, which depends on the reactive oxygen species (ROS) generated by a photosensitizer to kill cancer cells. The lack of selectivity and the over-production of glutathione (GSH) in cancer cells are the two major challenges for efficient and safe cancer PDT because they can cause harm to normal tissues and eliminate ROS in cancer cells. Herein, we report a GSH-responsive nanophotosensitizer based on CoOOH nanosheets for PDT of cancer. The nanophotosensitizer shows negligible photo-toxicity toward normal cells because of the quenching effect between CoOOH and photosensitizer Ce6. In the presence of overexpressed GSH, Ce6 molecules can be released into cancer cells because of GSH induced degradation of CoOOH nanosheets. In vivo experiments demonstrated that the tumor growth was efficiently inhibited by the CoOOH-based PDT strategy. The current nanophotosensitizer represents a promising smart platform to synergistically improve the therapeutic index and safety of PDT.

Graphical abstract: A GSH-responsive nanophotosensitizer for efficient photodynamic therapy

Supplementary files

Article information


Submitted
16 Oct 2018
Accepted
05 Dec 2018
First published
19 Dec 2018

This article is Open Access

RSC Adv., 2018,8, 42374-42379
Article type
Paper

A GSH-responsive nanophotosensitizer for efficient photodynamic therapy

W. Pan, M. Shi, Y. Li, Y. Chen, N. Li and B. Tang, RSC Adv., 2018, 8, 42374 DOI: 10.1039/C8RA08549H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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