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Issue 36, 2018, Issue in Progress
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Copper-catalyzed domino sequences: a new route to pyrido-fused quinazolinones from 2′-haloacetophenones and 2-aminopyridines

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Abstract

A new pathway to access pyrido-fused quinazolinones via a Cu(OAc)2-catalyzed domino sequential transformation between 2′-haloacetophenones and 2-aminopyridines was demonstrated. The solvent and base exhibited a remarkable effect on the transformation, in which the combination of DMSO and NaOAc emerged as the best system. Cu(OAc)2·H2O was more active towards the reaction than numerous other catalysts. This methodology is new and would be complementary to previous protocols for the synthesis of pyrido-fused quinazolinones.

Graphical abstract: Copper-catalyzed domino sequences: a new route to pyrido-fused quinazolinones from 2′-haloacetophenones and 2-aminopyridines

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Publication details

The article was received on 02 May 2018, accepted on 25 May 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA03744B
RSC Adv., 2018,8, 20314-20318
  • Open access: Creative Commons BY license
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    Copper-catalyzed domino sequences: a new route to pyrido-fused quinazolinones from 2′-haloacetophenones and 2-aminopyridines

    P. H. Pham, S. H. Doan, N. T. H. Vuong, V. H. H. Nguyen, P. T. M. Ha and N. T. S. Phan, RSC Adv., 2018, 8, 20314
    DOI: 10.1039/C8RA03744B

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