Jump to main content
Jump to site search

Issue 39, 2018, Issue in Progress
Previous Article Next Article

Evaluating the efficacy of the anticancer drug cetuximab by atomic force microscopy

Author affiliations

Abstract

Cetuximab is a monoclonal antibody that binds to the epidermal growth factor receptor, which is important in the growth of many cancers. However, the biophysical characteristics of cetuximab as an anti-cancer drug remain elusive. In this study, we adopted atomic force microscopy to measure the mechanical properties of cancer cells following cetuximab treatment and the biomechanical properties of cetuximab and epidermal growth factor receptor interactions. Atomic force microscopy can be implemented as a platform for further investigations that target the cellular stiffness and affinity of ligand–receptor as a therapeutic choice.

Graphical abstract: Evaluating the efficacy of the anticancer drug cetuximab by atomic force microscopy

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Apr 2018, accepted on 31 May 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA03215G
RSC Adv., 2018,8, 21793-21797
  • Open access: Creative Commons BY license
  •   Request permissions

    Evaluating the efficacy of the anticancer drug cetuximab by atomic force microscopy

    Q. Zhang, Y. Shi, H. Xu, L. Zhou, J. Gao, J. Jiang, M. Cai and Y. Shan, RSC Adv., 2018, 8, 21793
    DOI: 10.1039/C8RA03215G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements