Issue 35, 2018, Issue in Progress
From the journal:

RSC Advances

A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition†

Xuan Yu,a   Hui Bai,a   Dong Wang,a   Zhaohai Qin,a   Jia-Qi Li ORCID logo *a  and  Bin Fu*a  

* Corresponding authors

a Department of Applied Chemistry, China Agricultural University, West Yuanmingyuan Rd. 2, Beijing 100193, People's Republic of China
E-mail: jiaqili@cau.edu.cn, fubinchem@cau.edu.cn

Abstract

A Ni(II)-catalyzed enantioselective Michael addition of 2-acetyl azarenes with β-difluoromethyl substituted nitroalkenes was successfully realized, which afforded chiral CF2H-containing compounds in good enantioselectivities (up to 93% ee). This protocol provides a new convenient approach to all-carbon quaternary stereogenic centers featuring a CF2H group.

Graphical abstract: A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition

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Article information

DOI
https://doi.org/10.1039/C8RA02853B
Article type
Paper
Submitted
02 Apr 2018
Accepted
09 May 2018
First published
25 May 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 19402-19408

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A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(II)-catalyzed enantioselective Michael addition

X. Yu, H. Bai, D. Wang, Z. Qin, J. Li and B. Fu, RSC Adv., 2018, 8, 19402 DOI: 10.1039/C8RA02853B

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