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Issue 23, 2018, Issue in Progress
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Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

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Abstract

The delivery of drugs to the bloodstream via oral administration may suffer from a number of complications including poor dissolution, first pass metabolism and the active intervention of efflux transporters such as P-glycoproteins; drugs which are efflux substrates may cause considerable problems across many clinical conditions. Here we have employed a branch-polymer stabilised nanoemulsion strategy to create highly robust oil droplets (e.g. peanut oil, castor oil and soybean oil) containing different dissolved antiretroviral drugs used in the daily fight against HIV/AIDS. Although very limited difference in permeation through a Caco-2 gut epithelium model was seen for efavirenz, the permeation of the protease inhibitor lopinavir was considerably higher (approximately 10-fold) when applied to an epithelium monolayer in emulsion form than the control within an aqueous DMSO vehicle. The presented nanoemulsion approach may allow drug-specific permeation improvements for various drug substances.

Graphical abstract: Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

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Supplementary files

Article information


Submitted
05 Mar 2018
Accepted
28 Mar 2018
First published
09 Apr 2018

This article is Open Access

RSC Adv., 2018,8, 12984-12991
Article type
Paper

Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

J. J. Hobson, S. Edwards, Rebecca. A. Slater, P. Martin, A. Owen and S. P. Rannard, RSC Adv., 2018, 8, 12984
DOI: 10.1039/C8RA01944D

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