Jump to main content
Jump to site search

Issue 23, 2018, Issue in Progress
Previous Article Next Article

Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

Author affiliations

Abstract

We achieved the effective controllable regioselective acylation of the primary hydroxyl group of uridine derivatives catalyzed by Lipase TL IM from Thermomyces lanuginosus with excellent conversion and regioselectivity. Various reaction parameters were studied. These regioselective acylations performed in continuous flow microreactors are a proof-of-concept opening the use of enzymatic microreactors in uridine derivative biotransformations.

Graphical abstract: Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Feb 2018, accepted on 19 Mar 2018 and first published on 03 Apr 2018


Article type: Paper
DOI: 10.1039/C8RA01030G
RSC Adv., 2018,8, 12614-12618
  • Open access: Creative Commons BY license
  •   Request permissions

    Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor

    L. Du, J. Shen, Z. Dong, N. Zhou, B. Cheng, Z. Ou and X. Luo, RSC Adv., 2018, 8, 12614
    DOI: 10.1039/C8RA01030G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements