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Issue 19, 2018, Issue in Progress
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Cipadessains A–K, eleven limonoids from the fruits of Cipadessa cinerascens

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Abstract

Eleven new mexicanolide-type limonoids, cipadessains A–K (1–11), were isolated from the fruits of Cipadessa cinerascens (Pellegr) Hand.-Mazz. Their planar structures were determined based on IR, UV, 1D and 2D NMR spectra and HRESIMS data. The absolute configuration of 1 was elucidated by single-crystal X-ray diffraction using mirror Cu Kα radiation, and that of compounds 2–8 were determined by ECD analysis. Two mexicanolides bearing methoxybutenolide moiety originated from the furan ring 3 and 6, showed significant cytotoxicity against HepG2 cell line with IC50 values of 5.23 ± 0.12, 8.67 ± 1.02 μM, respectively; and NO inhibitory activities in LPS-activated RAW 264.7 macrophages at nontoxic concentration (IC50 5.79 ± 0.18, 6.93 ± 0.89 μM, respectively).

Graphical abstract: Cipadessains A–K, eleven limonoids from the fruits of Cipadessa cinerascens

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Supplementary files

Article information


Submitted
24 Jan 2018
Accepted
26 Feb 2018
First published
14 Mar 2018

This article is Open Access

RSC Adv., 2018,8, 10437-10445
Article type
Paper

Cipadessains A–K, eleven limonoids from the fruits of Cipadessa cinerascens

D. Sun, F. An, S. Wei, Y. Zhang, X. Wang, J. Luo and L. Kong, RSC Adv., 2018, 8, 10437
DOI: 10.1039/C8RA00728D

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