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Issue 29, 2018, Issue in Progress
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Long-term antibacterial performances of biodegradable polylactic acid materials with direct absorption of antibiotic agents

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Abstract

In this study, polylactic acid (PLA) disks with antibacterial performances were prepared using 3D printing technology combined with direct adsorption of the antibiotic agents in solution baths. The effects of the layer thicknesses for the building of the 3D printing PLA disks and the amounts of antibiotic agents absorbed onto the sample surfaces on their antibacterial activities were investigated. The antibiotic agent release profiles from the samples surface into the buffer solution show that the antibacterial performances of these samples can reach up to 28 days. With a decrease in the concentration of antibiotic agent in the solution bath, the amount of antibiotic agent adsorbed on the sample surfaces also decreases, but their antibacterial performances can still maintain at least 7 days. In the bioactivity tests of the various organisms, the release amount of antibiotic agent from the sample can inhibit E. coli and S. aureus for over 80% up to 28 days. In the antibacterial activity tests, a PLA disk with suitable antibiotic agents covering its surface has a good inhibitory effect on the growth ability of S. aureus of less than 50% in six hours.

Graphical abstract: Long-term antibacterial performances of biodegradable polylactic acid materials with direct absorption of antibiotic agents

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Supplementary files

Article information


Submitted
17 Jan 2018
Accepted
21 Apr 2018
First published
01 May 2018

This article is Open Access

RSC Adv., 2018,8, 16223-16231
Article type
Paper

Long-term antibacterial performances of biodegradable polylactic acid materials with direct absorption of antibiotic agents

C. Chen, Y. Yao, H. Tang, T. Lin, Dave W. Chen and K. Cheng, RSC Adv., 2018, 8, 16223
DOI: 10.1039/C8RA00504D

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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