Issue 26, 2018, Issue in Progress

Metabolomics analysis of salvage chemotherapy on refractory acute myeloid leukemia patients

Abstract

Acute myeloid leukemia (AML) is a group of hematological malignancies causing high mortality around the world. However, the treatment of AML is still one of the most formidable challenges. In this study, we employed a well-established global metabolic profiling platform, which combined ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with gas chromatography mass spectrometry (GC-MS) to investigate the metabolic alterations associated with salvage chemotherapy on 10 refractory acute myeloid leukemia (RAML) patients. A total of 390 metabolites were identified from 20 serum samples obtained from all 10 patients before and post salvage chemotherapy. The metabolomics profile was found to be very heterogeneous across the RAML patients. The results showed very subtle metabolic differences upon one-time chemotherapy treatment for an individual patient. Only 9 metabolites including imidazole lactate, glycerol 3-phosphate, three fatty acids, and four lysolipids in the blood serum were significantly changed before and post chemotherapy, suggesting their important roles during the development of RAML. This study may not only provide new insight into the metabolomics features in RAML patients, but also have relevance to improve the treatment and outcome of RAML.

Graphical abstract: Metabolomics analysis of salvage chemotherapy on refractory acute myeloid leukemia patients

Supplementary files

Article information

Article type
Paper
Submitted
13 Dec 2017
Accepted
10 Apr 2018
First published
18 Apr 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 14445-14453

Metabolomics analysis of salvage chemotherapy on refractory acute myeloid leukemia patients

Z. Zheng, P. Liu, L. Xu, Z. Peng, Y. Zhang, X. Chen, L. Hou, W. Cui, F. Tou, J. Rao and X. Fan, RSC Adv., 2018, 8, 14445 DOI: 10.1039/C7RA13298K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements