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Issue 33, 2018, Issue in Progress
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New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of Ziziphus cambodiana

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Abstract

Six new 14-membered ring cyclopeptide alkaloids, cambodines A–F (1–6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.

Graphical abstract: New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of Ziziphus cambodiana

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Publication details

The article was received on 05 Dec 2017, accepted on 02 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C7RA13050C
Citation: RSC Adv., 2018,8, 18204-18215
  • Open access: Creative Commons BY-NC license
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    New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of Ziziphus cambodiana

    N. Lomchoey, P. Panseeta, P. Boonsri, N. Apiratikul, S. Prabpai, P. Kongsaeree and S. Suksamrarn, RSC Adv., 2018, 8, 18204
    DOI: 10.1039/C7RA13050C

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