Issue 22, 2018, Issue in Progress
From the journal:

RSC Advances

DNA-induced synthesis of biomimetic enzyme for sensitive detection of superoxide anions released from live cell†

Ailing Ding,a   Bin Wang, ORCID logo *a   Xiaoqing Ma,a   Jianglin Diao,a   Jiushang Zheng,a   Jiucun Chena  and  Changming Li ORCID logo *a  

* Corresponding authors

a Institute for Clean Energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing 400715, P. R. China
E-mail: bwang@swu.edu.cn, ecmli@swu.edu.cn

Abstract

In this work, we successfully fabricate a rapid, sensitive sensor for the detection of superoxide anions O2˙− based on graphene/DNA/Mn3(PO4)2 biomimetic enzyme. In the design, graphene is served as excellent carrier to improve the catalysis of Mn3(PO4)2 nanoparticles; and DNA adsorbed on graphene acts as medium to assist the growth of Mn3(PO4)2 on graphene. The fabricated graphene/DNA/Mn3(PO4)2 composites exhibit excellently electrochemical activity, significantly decrease the response time and increase the sensitivity of the sensor towards O2˙−. The successful detection of O2˙− released from cancer cell demonstrated its potential applications in biology and medicine.

Graphical abstract: DNA-induced synthesis of biomimetic enzyme for sensitive detection of superoxide anions released from live cell

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Article information

DOI
https://doi.org/10.1039/C7RA12962A
Article type
Paper
Submitted
01 Dec 2017
Accepted
22 Mar 2018
First published
03 Apr 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 12354-12359

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DNA-induced synthesis of biomimetic enzyme for sensitive detection of superoxide anions released from live cell

A. Ding, B. Wang, X. Ma, J. Diao, J. Zheng, J. Chen and C. Li, RSC Adv., 2018, 8, 12354 DOI: 10.1039/C7RA12962A

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