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Issue 4, 2018
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Dimeric cinchona ammonium salts with benzophenone linkers: enantioselective phase transfer catalysts for the synthesis of α-amino acids

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Abstract

Chiral phase transfer catalysts of dimeric cinchona ammonium salts linked with a benzophenone bridge showed high enantioselectivity in the α-alkylation of a glycinate ester under mild industry-applicable conditions: 0.5 mol% PTC and near equivalents of alkyl halide. A dual function of the dimeric quinuclidiniums was proposed for the high efficiency.

Graphical abstract: Dimeric cinchona ammonium salts with benzophenone linkers: enantioselective phase transfer catalysts for the synthesis of α-amino acids

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Article information


Submitted
16 Nov 2017
Accepted
30 Dec 2017
First published
09 Jan 2018

This article is Open Access

RSC Adv., 2018,8, 2157-2160
Article type
Paper

Dimeric cinchona ammonium salts with benzophenone linkers: enantioselective phase transfer catalysts for the synthesis of α-amino acids

S. Woo, Y. Kim, B. Lim, J. Oh, Y. Lee, H. Gwon and K. Nahm, RSC Adv., 2018, 8, 2157
DOI: 10.1039/C7RA12499F

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