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Issue 76, 2017, Issue in Progress
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Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellum HDN13-309

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Abstract

Three new heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core, named trichodermamides D–F (1–3), together with the known trichodermamides A–C (4–6), were isolated from the broth of the mangrove-derived endophytic fungus Penicillium janthinellum HDN13-309. The structures were elucidated through extensive NMR spectroscopic and physical data. The absolute configurations of compounds 1–3 were determined by ECD calculations and single-crystal X-ray diffraction experiments. The cytoprotective activities were evaluated on different phase II detoxifying enzymes (SOD2, AKR1C1, HO-1 and NQO1), and compounds 4 and 6 showed potent inducing effects at the concentration of 10 μM.

Graphical abstract: Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellum HDN13-309

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Publication details

The article was received on 19 Sep 2017, accepted on 02 Oct 2017 and first published on 12 Oct 2017


Article type: Paper
DOI: 10.1039/C7RA10389A
RSC Adv., 2017,7, 48019-48024
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    Trichodermamides D–F, heterocyclic dipeptides with a highly functionalized 1,2-oxazadecaline core isolated from the endophytic fungus Penicillium janthinellum HDN13-309

    M. Zhu, Z. Yang, H. Feng, Q. Gan, Q. Che, T. Zhu, Q. Gu, B. Han and D. Li, RSC Adv., 2017, 7, 48019
    DOI: 10.1039/C7RA10389A

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