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Issue 70, 2017
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Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

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Abstract

A synthetic approach for 1,2-disubstituted benzimidazoles has been successfully designed based on effective C–N bond construction, which demonstrated mild reaction conditions and excellent yields. The method involves treating derivatives of o-phenylenediamine with tert-butanesulfoxide and NBS under acidic conditions, which undergoes an aza-Wittig-equivalent process to afford the desired products. Using this method, a series of benzimidazoles containing multiple functional groups with varying electronic effects have been successfully constructed.

Graphical abstract: Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

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Article information


Submitted
15 Aug 2017
Accepted
09 Sep 2017
First published
15 Sep 2017

This article is Open Access

RSC Adv., 2017,7, 44421-44425
Article type
Paper

Synthesis of 1,2-disubstituted benzimidazoles using an aza-Wittig-equivalent process

Y. Chen, F. Xu and Z. Sun, RSC Adv., 2017, 7, 44421
DOI: 10.1039/C7RA09010B

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